Journal: Molecules

Article Title: Synthesis and Pharmacological Effects of Diosgenin–Betulinic Acid Conjugates

doi: 10.3390/molecules25153546

Figure Lengend Snippet: Cytotoxicity screening tests (IC 50 values (μM), 72 h).

Article Snippet: The compounds 1 – 8 were subjected to the cytotoxicity screening tests on cells of human T-lymphoblastic leukemia (CEM), cells of human breast adenocarcinoma (MCF7), cells of human cervical cancer (HeLa), and human colon carcinoma (HCT 116 cancer cell lines), using normal human fibroblasts (BJ) as reference cell lines.

Techniques:

Journal: ACS Omega

Article Title: Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates

doi: 10.1021/acsomega.3c03387

Figure Lengend Snippet: Plots of expected enhancement rates in DNA dsb in HeLa cells (A) × (C) shown in Table vs enhancement rates in cytotoxicity against HeLa cells (B) for 1 P1–3 (red line) and 1M 1–3 (purple line). The slopes of the red and blue lines are 0.44 and 0.053, respectively.

Article Snippet: Prof. Kitagishi provided HeLa (human cervical cancer) cells used in this study (Doshisha University, Kyoto, Japan).

Techniques:

Journal: ACS Omega

Article Title: Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates

doi: 10.1021/acsomega.3c03387

Figure Lengend Snippet: Confocal microscopic images of 1 P1–3 (200 μM) in HeLa cells in the dark on 1 h incubation. Bright-field images (A, E, I). Blue fluorescence indicates the fluorescence of 1 P1 (B), 1 P2 (F), and 1 P3 (J) (λ ex = 405 nm). Red fluorescence is mitochondrial staining by Mito Tracker Deep Red FM (50 nM) (Thermo Fisher) (C, G, K) (λ ex = 640 nm). (D, H, L) Overlay images of panels (A)–(C), (E)–(G), and (I)–(K), respectively. The scale bar is 20 μm.

Article Snippet: Prof. Kitagishi provided HeLa (human cervical cancer) cells used in this study (Doshisha University, Kyoto, Japan).

Techniques: Incubation, Fluorescence, Staining

Journal: ACS Omega

Article Title: Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates

doi: 10.1021/acsomega.3c03387

Figure Lengend Snippet: In Vitro Cytotoxicity of 1 , 1 X , and Cisplatin against Various Cells in MTT Assay (48 h) (Mean ± SD)

Article Snippet: Prof. Kitagishi provided HeLa (human cervical cancer) cells used in this study (Doshisha University, Kyoto, Japan).

Techniques: In Vitro, MTT Assay

Journal: ACS Omega

Article Title: Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates

doi: 10.1021/acsomega.3c03387

Figure Lengend Snippet: Data for the Plot of Expected Enhancement Rates ( 1 X / 1 ) in DNA dsb in HeLa Cells (A) × (C) vs Enhancement Rates ( 1 X / 1 ) in Cytotoxicity against HeLa Cells (B) a

Article Snippet: Prof. Kitagishi provided HeLa (human cervical cancer) cells used in this study (Doshisha University, Kyoto, Japan).

Techniques: